1030 アルギン酸ゲル微粒子を用いた薬物担体の創製(G02-4 バイオエンジニアリング(4),G02 バイオエンジニアリング)

概要

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Because of its high biocompatibility, calcium alginate gel beads and poly-L-lysine alginate gel have been used as a scaffold biomaterial for culturing chondrocyte or semipermeable separating membrane for entrapment of pancreatic β-islet. In this study, we tried to produce calcium alginate gel particles and microcapsules as drug carriers. The diameter of the microcapsules was greater than 5μm. We investigated an elastic characteristic of the microcapsules by using a micro-manipulator system. As a result, the following characteristics were clarified; microcapsules showed an elastic deformation over 70% deformation of its diameter. It took several minutes to recover the undeformed shape. The deformability of the microcapsule is superior to that of the solid alginate gel particle.
社団法人日本機械学会の論文
2007-09-07