1103 喘息の模擬実験 : 呼吸器系における気道の座屈に関する生体外実験(S02-1 循環器系・呼吸器系の生体機能モデリング(1),S02 循環器系・呼吸器系の生体機能モデリング)

概要

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Bronchial asthma causes an airway narrowing and so makes breathing difficult. It is important to clarify its mechanism. The characteristic of the airway narrowing is that its buckled cross-section consists of many folds in the airway lumen. It is considered to be caused by a rapid constriction of smooth muscle. We paid attention to a rapid change in the transmural pressure as a model of the constriction of smooth muscle. In this study, to clarify the mechanism of the buckling, we used collapsible tubes as a model of the airway and used a shock tube which gave a sudden decrease in the pressure inside the collapsible tube. The cross-sectional shape of the tube was visualized by a laser sheet method and its behavior during the buckling was photographed by using a high speed video camera. We examined the influence of thickness of a collapsible tube wall and Young's modulus of the tube on buckling behavior.
社団法人日本機械学会の論文
2007-09-07