1120 マイクロチャンネルを用いた毛細血管中の赤血球の挙動と変形能に関する生体外実験と解析(J05-1 血液循環系のバイオエンジニアリング:医療技術への展開(1),J05 血液循環系のバイオエンジニアリング:医療技術への展開)

概要

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In human body, erythrocytes deform highly and can smoothly pass through capillaries of which diameters are narrower than the cells'. Since capillaries connect all organs in a body, decrease of erythrocytes deformability causes several diseases. Therefore it is very important to evaluate the dynamic deformability of the erythrocyte at the microcirculation level. In this research, we fabricated a micro channel array with a 5μm×5μm square cross section of 100μm in length on a silicone chip to simulate capillaries. After whole blood was centrifuged and erythrocytes were separated from plasma, the erythrocytes were diluted with the autologous plasma by a hematocrit of 10%. This suspension was made to flow through the micro channels. The motion of the erythrocyte was photographed using a high-speed video camera. A shape recovery process of the erythrocytes after getting out of the channel was modeled by Kelvin viscoelastic model. As a result, The Kelvin model explained well its process.
2007-09-07