1113 喘息の模擬実験 : 呼吸器系における気道の座屈に関する生体外実験(GS-2,5 計測,研究発表講演)

概要

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Bronchial asthma is a kind of chronic bronchitis. It causes the airway narrowing happen and so makes breathing difficult. It is important to clarify its mechanism. The characteristic of asthmatic airway is that its buckling consists of some folds into the airway lumen. It is considered to be caused by rapid constriction of smooth muscle. We paid attention to a rapid change in the transmural pressure as a model of the constriction of smooth muscle. In this study, to clarify the mechanism for buckling, we used collapsible tubes as a model of the airway and made apparatus which gave a sudden decrease in the pressure inside the collapsible tube by using a shock tube. The shape of the cross-section on the tube was visualized by a laser sheet method and its behavior during the buckling was photographed by using a high speed video camera. Besides, to use the expanding model, we could derive similarity rule in our experiments.
一般社団法人日本機械学会の論文
2005-03-18