626 微小流路中の赤血球の変形挙動に関する実験 : 変形能が形状回復過程に及ぼす影響(G02-4 血流(1),G02 バイオエンジニアリング)

概要

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In a human body, erythrocytes deform highly and can smoothly pass capillaries of which diameters are narrower than the cells'. Since capillaries connect all organs in a body, decrease in erythrocytes deformability causes several diseases. Therefore it is very important to evaluate the dynamic deformability of the erythrocyte at the microcirculation level. In this research, we produced a micro channel array with a 5μm×5μm square cross section of 100μm in length on the silicone chip to simulate capillaries. After whole blood was centrifuged and erythrocytes were separated from plasma, the erythrocytes were diluted with autologous plasma by a hematocrit of 10%. This suspension was made to flow through the micro channels. Erythrocyte was observed using a high-speed video camera each day during preservation period. As a result, it was found that erythrocyte gradually decreased its deformability as the preservation period were getting longer.
一般社団法人日本機械学会の論文
2006-09-15