G0200-3-6 喘息の生体外模擬実験 : 粘膜下組織と基底膜から成る細気管支モデルの座屈(バイオエンジニアリング部門一般講演(3),社会変革を技術で廻す機械工学)

概要

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Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness. Asthmatic airway is thickened and stiffened by remodeling. Many folds on the surface of airway appear by the constriction of smooth muscle and buckles. Because, the number of occurring folds decreases in the asthmatic airway, and the airway lumen becomes stenosed. As a result, it is thought that the breathing difficulties occur. It is important to clarify the buckling mechanism in the airway. In this study, to clarify the mechanism of the buckling, we used two-layered collapsible tubes as a model of the bronchiole and used a shock tube which gave a sudden decreasing in the pressure inside the tube. The tube cross-section area was visualized by using laser sheet technique, and a high speed video camera. As a result, the number of folds increased with increase in the elastic ratio.
一般社団法人日本機械学会の論文
2010-09-04