J0203-3-3 マイクロチャンネルを用いたヒト赤血球の形状回復に関する時定数の測定(医療診断のためのマルチスケール血流動態計測と解析(3))

概要

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In human body, erythrocytes can deform very flexibly and pass smoothly through capillaries. Since nutrient and gas exchanges between organs and blood are carried out at capillary level all over the body, decrease in erythrocytes deformability causes several diseases. Hence it is very important to evaluate the dynamic deformability of erythrocyte flowing in microcirculation. In this study, we used a micro-channel array with 5μm×5μm square cross-section and 100μm in length on PDMS. Blood from healthy and diabetic persons were diluted by a hematocrit of 1% with PBS, and a suspension of glutaraldehyde-hardened erythrocyte from healthy person was prepared. These suspensions were made to flow through the micro-channels. The motion of each erythrocyte was photographed using a high-speed video camera. In analysis of these experimental results, the shape recovery process of each erythrocyte was modeled by the Kelvin viscoelastic model. As a result, the time constant of shape recovery of erythrocyte became shorter in order of healthy, diabetic, and hardened-erythrocytes.
社団法人日本機械学会の論文
2009-09-12