707 マイクロチャンネルを用いた赤血球形状回復能の計測と評価(J06-2 医療診断のためのマルチスケール血流動態計測と解析(2),ジョイントセッション,21世紀地球環境革命の機械工学:人・マイクロナノ・エネルギー・環境)

概要

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In a human body, erythrocytes deform highly and can smoothly pass capillaries of which diameters are narrower than the cells'. Since capillaries connect all organs in a body, decrease in erythrocytes deformability causes several diseases. Therefore it is very important to evaluate the dynamic deformability of the erythrocyte at the microcirculation level. In this research, we produced a micro channel army with a 5μm×5μm square cross section of 100μm in length on the silicon substraight to simulate capillaries. After whole blood was centrifuged and erythrocytes were separated from plasma, the erythrocytes were diluted with autologous plasma by a hematocrit of 10%. This suspension was made to flow through the micro channels. Erythrocyte was observed using a high-speed video camera each day during preservation period. As a result, the time fluctuations of compressive strain of the RBCs agree with the theoretical curve of first-order lag element as a viscoelastic Kelvin model.
2008-08-02