1106 フェムト秒レーザー3次元微細加工装置を用いた毛細血管モデルの作製と模擬実験 : 物質交換モデルの試作(S02-2 循環器系・呼吸器系の生体機能モデリング(2),S02 循環器系・呼吸器系の生体機能モデリング)

概要

論文の詳細を見る
Capillaries are microvessels of 5〜10μm in diameter, which play an important role in the exchange of mass. To clarify the blood flow in capillaries, we have fabricated a realistic model of a capillary vessel inside a silica glass using a femtosecond laser micro fabrication system. The present model consists of a main microtube of 10pm in diameter and seventeen side micro tubes of 1μm in diameter connected to the side wall of the main microtube for simulating mass exchange function of capillaries. We have succeeded in observing red blood cells (RBCs) and tracer particles of 0.2μm or 0.5μm in diameter flowing in this micro-model using a flow visualization technique. It has been observed that tracer particles go out of the main tube via side tubes in its upstream part, and they go back to the main tube via side tubes in its downstream part, while RBCs flow only through the main microtube. Hence, it is considered that our model can reproduce the plasma flow in exchange of gas and nutrients in capillaries.
一般社団法人日本機械学会の論文
2007-09-07