Inhibitory Effect of Relaxin-3 on Insulin Secretion in Isolated Pancreas and Insulinoma
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概要
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Relaxin-3 is a recently discovered member of the insulin superfamily and is a ligand for three orphan G-protein-coupled receptors: GPCR135, GPCR142 and LGR7 (leucine-rich repeat-containing G-proteincoupled receptor 7). GPCR135 mRNA is expressed in the pancreas, however, it is not known, whether the peptide affects pancreatic islet function. Reverse transcriptase (RT)-PCR and radioreceptor assay have shown that the relaxin-3 receptor (GPCR135) is expressed in pancreatic islets and rat insulinoma, but LGR7 is not expressed. Moreover, relaxin-3 has been revealed to inhibit the secretion of insulin from pancreatic islets. However, we can not detect relaxin-3 in small intestine and pancreas. These results suggest a novel role of relaxin-3 in the regulation of insulin release.
- 2009-02-01
著者
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Yamamoto Hiroyuki
Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Arai Takeo
Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Tasaka Ryota
Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Mori Yasunori
Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Iguchi Kazuaki
Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Unno Keiko
Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Hoshino Minoru
Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Mori Yasunori
Laboratory Of Bioorganic Chemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Iguchi Kazuaki
Laboratory Of Bioorganic Chemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Iguchi Kazuaki
Lab. Of Bioorganic Chemistry School Of Pharmaceutical Sciences Univ. Of Shizuoka
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Tasaka Ryota
Laboratory Of Bioorganic Chemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Hoshino Minoru
Laboratory Of Bioorganic Chemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Unno Keiko
Laboratory Of Bioorganic Chemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Arai Takeo
Laboratory Of Bioorganic Chemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Yamamoto H
Sharp Corp. Nara Jpn
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Yamamoto H
College Of Science And Technology Nihon University
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Yamamoto H
Laboratory Of Bioorganic Chemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Unno Keiko
Laboratory Of Bioorganic Chemistry Pharmaceutical Sciences University Of Shizuoka
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Yamamoto Hitoshi
Department Of Chemistry Faculty Of Engineering Gifu University
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Yamamoto Hiroyuki
Laboratory For Biopolymer Chemistry Department Of Polymer Science And Engineering Kyoto Institute Of
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