Induction of Cyclooxygenase-2 Expression by Interleukin-1β in Human Glioma Cell Line, U87MG
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概要
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Cyclooxygenase-2 (COX-2) is up-regulated in most high-grade gliomas, and high COX-2 expression is associated with aggressive character and poor prognosis. However, the effect of COX-2 in human glioma cell lines is not well known. This study examined the effect of several stimuli, including interleukin-1β (IL-1β) and carcinogens, on COX-2 induction in normal astrocyte cells and human glioma cell lines U87MG, A172, and T98G. IL-1β-induced COX-2 expression strongly at both protein and messenger ribonucleic acid levels in only the U87MG cells of the glioma cell lines. Furthermore, carcinogen induced COX-2 expression. Similar findings were also observed in normal human astrocyte cells. The U87MG glioma cell line is a good model for COX-2 induction in glioma cell lines.
- 社団法人日本脳神経外科学会の論文
- 2008-11-15
著者
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Watanabe Takashi
Department of Chemistry, Graduate School of Science, Kyoto University
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Kamitani Hideki
Department Of Neurosurgery Faculty Of Medicine Tottori University
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Taniura Seijiro
Department Of Neurosurgery Institute Of Neurological Sciences Faculty Of Medicine Tottori University
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ELING Thomas
Laboratory of Molecular Carcinogenesis, National Institutes of Environmental Health Sciences
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Eling Thomas
Laboratory Of Molecular Carcinogenesis National Institutes Of Environmental Health Sciences
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Watanabe Takashi
Department Of Applied Physics Tohoku University
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