Cerebral Ischemia Promotes Rich Pseudopalisading Necrosis in the Rat C6 Glioblastoma Model
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概要
- 論文の詳細を見る
The effect of hypoxia on glioma growth including pathological changes was investigated in an experimental model of brain ischemia in the rat C6 glioma model. C6 glioma cells were inoculated into the subcortex of adult Wistar rats. Focal cerebral ischemia near the implanted glioma area was induced by permanent middle cerebral artery occlusion (PMCAO). Ten days later, the rats were sacrificed to compare tumor volume of C6 glioma without PMCAO (control group) versus C6 glioma with PMCAO (hypoxia group). The histological features were also observed. The mean tumor volume in the hypoxia group was significantly larger than that in the control group. The most prominent histological finding in the hypoxia group was abundant formation of pseudopalisading around the necrotic areas. Immunohistological examinations showed intensive staining for vascular endothelial growth factor and hypoxia-inducible factor in these pseudopalisading cells. These findings suggest that cerebral ischemia positively modulates glioma mass growth by the formation of pseudopalisading necrosis, a characteristic histological finding of glioblastoma.
- 社団法人 日本脳神経外科学会の論文
- 2009-07-15
著者
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Watanabe Takashi
Department of Chemistry, Graduate School of Science, Kyoto University
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KINOSHITA Yusuke
Department of Neurosurgery, Faculty of Medicine, Tottori University
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KAMITANI Hideki
Department of Neurosurgery, Faculty of Medicine, Tottori University
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Mamun Mahabub
Department Of Neurosurgery Institute Of Neurological Sciences Faculty Of Medicine Tottori University
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Kamitani Hideki
Department Of Neurosurgery Tottori Prefectural Kousei Hospital
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Kamitani Hideki
Department Of Neurosurgery Faculty Of Medicine Tottori University
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Kinoshita Yusuke
Division Of Neurosurgery Department Of Brain And Neurosciences Faculty Of Medicine Tottori Universit
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Kinoshita Yusuke
Department Of Neurosurgery Faculty Of Medicine Tottori University
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TABUCHI Sadaharu
Department of Neurosurgery, Institute of Neurological Sciences, Faculty of Medicine, Tottori Univers
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WASITA Brian
Department of Neurosurgery, Institute of Neurological Sciences, Faculty of Medicine, Tottori Univers
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Wasita Brian
Division Of Neurosurgery Department Of Brain And Neurosciences Faculty Of Medicine Tottori Universit
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Tabuchi Sadaharu
Department Of Neurosurgery Institute Of Neurological Sciences Faculty Of Medicine Tottori University
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Watanabe Takashi
Division Of Neurosurgery Department Of Brain And Neurosciences Faculty Of Medicine Tottori Universit
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Watanabe Takashi
Department Of Cardiothoracic Surgery Nagoya University School Of Medicine
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Kamitani Hideki
Division Of Neurosurgery Faculty Of Medicine Institute Of Neurological Sciences Tottori University
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Watanabe Takashi
Department Of Applied Physics Tohoku University
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KINOSHITA Yusuke
Department of Mechanical Engineering and Science, Kyoto University
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