72 新セスタテルペン抗生物質terpestacin (BU-4641V)に関する研究(ポスター発表の部)

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Recent research results evidently indicated that human immuno deficiency virus(HIV) is the major etiological agent of HIV. The HIV envelope glycoprotein, gp-160, is essential for the viral entry into cells. The gp-120 expressed on HIV-infected cells interact with CD4 surface antigen on target cells. This interaction precedes a post-binding fusion event mediated by the HIV transmenbrane gp-41, leading to a multinucleated giant cell called syncytium. From this point of view, syncytium formation inhibitors are potential anti-HIV agents. We reported here the fermentation, isolatiton, absolute structure, stereospecific biosynthesis and activity of a syncytium formation inhibitor, terpestacin (BU-4641V 1), which is a sesterterpen group of antibiotic having a novel bicyclic 5- and 15-menbered ring skeleton from Arthrinium sp. FA 1744(ATCC 74132). 1 inhibited syncytiu formation at 0.46 μg/ml.
天然有機化合物討論会の論文
1992-09-10