58. 植物由来放線菌からの植物生理活性物質の探索

概要

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Inhibitors and promoters of plant growth are useful in controlling the plant growth. In addition, there are examples of natural products which were originally isolated in the screening of plant growth regulation but were found to have biologically important activity such as tublin inhibitor or protein kinase inhibitor as seen in pironetin or herbimycin. Thus, the screening of bioactive compounds using plant can be expected to lead a discovery of new compounds that can not be detected in the screening using mammalian cells or microorganisms. In the screening of plant bioactive compounds from endophytic actinomycetes, we found pteridic acids as an auxin-like plant growth promoter from Streptomyces hygroscopicus TP-A0451. The fermentation extract of this strain was fractionated and each fraction was analyzed by LC/MS and rice germination test. As a plant growth inhibitor, antibiotic TAN420, azalomycin B and several unknown compounds were identified. Isolation, structure analysis and evaluation of bioactivity of unknown compounds are in progress.
植物化学調節学会の論文
2004-10-13