P-46 新規srcシグナルトランスダクション阻害剤エンジェルマイシンの構造解析(ポスター発表の部)

概要

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In 1993, Y. Uehara and T. Oki discovered angelmicins as new src Signal transduction inhibitors. Angelmicins inhibited src tyrosine kinase and oncogenic signal transduction. We elucidated the structures of angelmicins. The inhibitors were produced by a strain of rare actinomycetes Microbispora sp., and were purified from the fermentation broth using column and thin layer chromatography. FAB-MS analysis of angelmicin B showed [M]^+ at m/z 1724.7. A molecular formula of angelmicin B was determined to be C_<85>H_<11>2O_<37> on the basis of the elemental analysis and the ^<13>C and ^1H-NMR spectra. The structure was elucidated on the basis of some NMR spectra such as COSY, TOCSY, PFG-HMBC, hetero NOE and double LSPD. It was found that angelmicin B contained three pair of deoxyhexose residues, digitoxose amicetose and 4-C-acetyl-2,3,6-trideoxy hexopyranose. The aglycon consisited of eight fused six membered rings containing highly oxidized naphthylnaphthoquinone portion as a chromophore. Total structure of angelmicin B was determined as shown in figure 8. The absolute configuration have not yet been determined.
天然有機化合物討論会の論文
1995-09-01