87 制癌性および発癌性物質による修飾核酸塩基の構造
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概要
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Mitomycin C, a potent antibiotic and clinically useful antitumor agent, was reductively activated and reacted with 5'-guanylic acid. The structure of the adduct was determined as cis-2,7-diamino-1-(5'-guanylyl) mitosene (4). Two potent mutagens, 3-amino-1-methyl-5H-pyrido[4,3-b]-indole (Trp-P-2), isolated from a tryptophan pyrolysate, and 2-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole (Glu-P-1), isolated from a glutamic acid pyrolysate, modified DNA in the presence of rat liver microsomes. The major base modified with Trp-P-2 was identified with 3-(C^8-guanyl)amino-1-methyl-SH-pyrido[4,3-b]indole (9). The major base modified by Glu-P-1 was identified with 2-(C^8-guanyl)amino-6-methyldipyrido-[1,2-a: 3',2'-d]imidazole (14).
- 1980-09-10
著者
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首藤 紘一
東大薬学
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岡本 敏彦
東大薬
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橋本 祐一
東大薬
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岡本 敏彦
Faculty Of Pharmaceutical Sciences University Of Tokyo
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首藤 紘一
東京大・薬学
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