29 ポリエンの閉環反応によるテルペノイドの合成-II

概要

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In connection with the biogenetic type synthesis of natural products presented at 19th symposium of natural products(1975), further studies concerning the following topics were continued. I. Brominative cyclization of polyenes We have already found that TBCO(2,4,4,6-tetrabromocyclohexadienone) is suitable for the introduction of bromine atom at the terminal double bond of polyenes. Reactivity of TBCO was found to be divided into three types 1, 2, and 3. Snyderols (5a,b) was synthesized from nerolidol (22). II. Acylation of polyenes From chloroketone (23), cembrene type natural products (26), (34), (35), (36), and (37) were synthesized. d- and 1-neocembrene showed the same pheromone activities toward the termite. Acylation of (42), (44), and (46) were also tried to give (43), (45), and (48), respectively.
天然有機化合物討論会の論文
1976-09-20