フルオロキノロン系抗菌剤に対する耐性乳酸菌および酪酸菌製剤の感受性について

概要

論文の詳細を見る
Antibiotic-resistant lactic acid bacteria (RLAB) and clostridium butyricum (CB) preparations are often used to improve symptoms resulting from antibiotic-induced changes in intestinal flora. However, though the resistance of these preparations to fluoroquinolones (FQs) has not been sufficiently studied, they are sometimes prescribed in combination with FQs under off-label use. The reason for this is thought to be that all RLAB and CB preparations are considered to be resistant to all antibiotic agents. In this study, we determined the minimal inhibitory concentrations of FQs with respect to strains isolated from five RLAB and one CB preparation using the microdilution method. Furthermore, the susceptibility to FQs of the strains isolated from the RLAB preparations was compared with that of strains isolated from conventional lactic acid preparations. The strains from most of the RLAB preparations and that from the CB preparation were found to be susceptible to FQs. There was also no difference in bacterial resistance between the RLAB and conventional lactic acid preparations. The concurrent use of RLAB and FQs under off-label use should therefore be avoided.
日本医療薬学会の論文
2008-01-10