In Vitro Immunoregulatory Effects of Korean Mistletoe Lectin on Functional Activation of Monocytic and Macrophage-Like Cells(Pharmacology)

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概要

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• Korean mistletoe lectin (KML) is one of the major active components in Viscum album var. (coloratum), displaying various biological effects such as anti-tumor and anti-metastatic activities. Even though it has been shown to boost host immune defense mechanisms, the immunomodulatory effects of KML on specific immune responses mediated by macrophages have not been fully elucidated. Therefore, in this study, we aimed to demonstrate KML's regulatory roles on macrophage-mediated immune responses. KML clearly blocked lipopolysaccharide (LPS)-induced events [expression of interleukin (IL)-10, nitric oxide (NO) production and phagocytic uptake], and suppressed the normal expression levels of IL-10 (at 2ng/ml) and tumor necrosis factor (TNF)-α (at 10ng/ml). In contrast, (1) the expression of cytokine (TNF-α) and (2) the generation of reactive oxygen species (ROS) induced by LPS were significantly up-regulated with KML co-treatment. In addition, KML itself increased the mRNA levels of IL-3 and IL-23 ; phagocytic uptake ; the surface levels of co-stimulatory molecules (CD80 and CD86), pattern recognition receptors (PRRs) [such as dectin-1 and toll like receptor (TLR)-2] and adhesion molecules [β1-integrins (CD29) and CD43] ; and CD29-mediated cell adhesion events. Finally, according to co-treatment of D-galactose with KML under LPS-induced NO production conditions, KML inhibition seems to be mediated by binding to proteins with D-galactose. Therefore, these data suggest that KML may participate in regulating various macrophage-mediated innate and adaptive responses via binding to surface protein with D-galactose and that some of these may deserve in KML's therapeutic activities such as anti-tumor and antimicrobial effects.

• 公益社団法人日本薬学会の論文
• 2007-11-01

著者

• Cho Jae

  School Of Bioscience And Biotechnology And Inst. Of Bioscience And Biotechnology Kangwon National Un

• LEE Yong

  School of Electrical Engineering, Seoul National University

• Rhee Man

  Department Of Physiology College Of Veterinary Medicine Kyungpook National University

• LEE Ji

  School of Bioscience and Biotechnology, and Institute of Bioscience and Biotechnology, Kangwon Natio

• KIM Joo

  School of Bioscience and Biotechnology, and Institute of Bioscience and Biotechnology, Kangwon Natio

• BYEON Se

  School of Bioscience and Biotechnology, and Institute of Bioscience and Biotechnology, Kangwon Natio

• KIM Byung

  School of Bioscience and Biotechnology, and Institute of Bioscience and Biotechnology, Kangwon Natio

• LEE Albert

  Department of Materials Science and Engineering, Univeristy of Illinois-Urbana-Champaign

• KWON Moosik

  Department of Genetic Engineering, Sungkyunkwan University

• HONG Sungyoul

  Department of Genetic Engineering, Sungkyunkwan University

• Byeon Se

  School Of Bioscience And Biotechnology And Institute Of Bioscience And Biotechnology Kangwon Nationa

• Lee Albert

  Department Of Materials Science And Engineering Univeristy Of Illinois-urbana-champaign

• Kwon Moosik

  Department Of Genetic Engineering Sungkyunkwan University

• Hong Sungyoul

  Department Of Genetic Engineering Sungkyunkwan University

• Kim Joo

  School Of Bioscience And Biotechnology And Institute Of Bioscience And Biotechnology Kangwon Nationa

• Lee Yong

  School Of Earth And Environmental Sciences Seoul National University

• Cho Jae

  School Of Bioscience And Biotechnology And Institute Of Bioscience And Biotechnology Kangwon Nationa

• Lee Ji

  School Of Bioscience And Biotechnology And Institute Of Bioscience And Biotechnology Kangwon Nationa

• Lee Yong

  School Of Bioscience And Biotechnology And Institute Of Bioscience And Biotechnology Kangwon Nationa

• Kim Byung

  School Of Bioscience And Biotechnology And Institute Of Bioscience And Biotechnology Kangwon Nationa

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