Chloroquine, an Anti-malarial Agent, Acts as a Novel Regulator of β1-Integrin-Mediated Cell-Cell Adhesion(Molecular and Cell Biology)
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概要
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Chloroquine is one of the disease-modifying antirheumatic drugs (DMARDs) with anti-malarial effect. In this study, we examined the modulatory effect of chloroquine on the functional activation of β1-integrins (CD29) using CD29- and CD98 (a functional regulator of CD29)-mediated U937 cell-cell adhesion, comparing macrophage functions and T cell proliferation. Chloroquine effectively suppressed U937 cell-cell adhesion mediated by CD29 and CD98, in a protein kinase (PK) C, PKA, protein tyrosine kinase (PTK), extracellular signal-regulated kinase (ERK) and actin cytoskeleton-independent manner. Other lysonlotropic agents (monesin, methylamine and ammonium chloride) also significantly diminished both CD29- and CD98-mediated cell-cell adhesion, indicating that lysomotropic character may play a critical role in regulating β1-integrin functions. Therefore, these results suggest that chloroquine may act as a novel regulator of CD29 function in a lysomotropic character-dependent novel manner.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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Cho Jae
School Of Bioscience And Biotechnology And Inst. Of Bioscience And Biotechnology Kangwon National Un
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Cho Jae
School Of Bioscience And Biotechnology And Institute Of Bioscience And Biotechnology Kangwon Nationa
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