畜牛における全身性類澱粉症について

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Histopathological investigation was made of 3 cases of aged cattle affected with generalized secondary amyloidosis. 1) Macroscopically the outstanding changes found were undernutrition and edema. The kidneys had undergone the most extensive changes. The kidneys in all cases were swollen, pale yellow in colour and usually showed yellowish-white spots in the cortex area. A general diffuse catarrhal inflammation and edema of the intestine was also observed. In one of the cases (case 1), the liver was anemic, slightly swollen and had a firm consistency. Further, mastitis was found in all cases, pneumonia apostematosa in one case (case 1) and peritonitis chronica in one case (case 3). 2) Microscopically the most characteristic changes were observed in the kidneys; namely, amyloid deposits in the renal corpuscles and interstitial connective tissue of the medulla. A parenchymatous degeneration, such as hyaline drop degeneration was conspicuous in the convoluted tubules. The amyloid deposits were also observed in the liver, forestomach, intestinal tract, lymph nodes, adrenal glands, pancreas, lungs (except case 2) and heart (except case 1). 3) The amyloid substance was seen as red homogenous material with hematoxylineosin staining. This substance stains blue with Azan, pale purplish red with methyl violet, pale red with cogo red, positive for PAS and iodine reaction. On fluorochromic staining with thioflavin T, the substance appeared bright green yellow under fluoresence microscopy. 4) The present cases can be classified into the typical type of generalized secondary amyloidosis. Etiologically, it is considered that a close relationship exists between chronic purulent inflammation and the occurence of mastitis.
1973-01-18

畜牛における全身性類澱粉症について

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