トキソプラズマBeverley株腹腔内接種マウスの病理組織像
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概要
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The present research was performed to investigate histopathological findings of experimental toxoplasmcsis of mice. Nineteen ICR-JCL stock female mice 57±1 days old weighing 23 to 24g were used. Mice were inoculated intraperitoneally with about 10^2 cysts of the Beverley strain obtained from the brains of infected mice. Two infected mice were sacrificed on the 2nd, 4th, 7th, 11th, 14th and 35th days after inoculation. The organs from these mice were fixed in 10% formalin solution and embedded in paraffin. Sections were stained with hematoxylin and eosin and PAS staining. Histopathological findings obtained from the present research were compared with those from mice infected with the RH strain in the previous study. The results obtained are summarized as follows : Three mice died during the period of the experimients. On the 2nd day cell-accumulations mainly consisting of histiocytes and containing a few organisms of proliferative form were recognized in the peritoneum and the capsules of the organs in the peritoneal cavity. On the 4th day cell-accumulations were recognized in the peritoneum and the liver. On the 7th day these changes progressed and were recognized in various organs throughout the body. In addition organisms of proliferative form also appeared in the spleen, uterus, mesenteric lymph node and brain, although the process of multiplication of organisms and the degree of necrotic changes were milder in the Beverley strain than in the RH strain. On the 11th day and after, generally, histopathological changes of the organs in the peritoneal cavity regresssed gradually in accordance with the disappearance of organisms. Organisms of cyst form appeared first on the 11th day in the brain. On the 14th and 35th day cysts were recognized in the heart, lung and brain and histopathological changes were observed mainly in the lung and brain. In the thymus pathological involution was recognined on the 7th, 11th, and 14th days.
- 帯広畜産大学の論文
- 1976-06-25
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