Improvement of Force Modulation Mode with Scanning Probe Microscopy for Imaging Viscoelasticity of Living Cells

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概要

• 論文の詳細を見る

• We improved the force modulation mode with scanning probe microscopy (SPM) in order to make a quantitative evaluation of the viscoelasticity of living cells. Taking account of the viscosity of liquid medium, the vibration frequency of the cantilever was selected to be 500 Hz, and analysis of cantilever vibration was adopted for evaluation of the viscoelasticity of the samples. Consequently, we have succeeded in determining viscoelasticity distribution on living cells. The values of Young's modulus and the coefficient of viscosity vary from 10 to 50 kPa and from 20 to 40 Pa·s on a cell, depending on its internal cellular structure.

• 社団法人応用物理学会の論文
• 2002-07-30

著者

• Kawabata K

  Division Of Physics Graduate School Of Science Hokkaido University

• KAWABATA Kazushige

  Division of Physics, Graduate School of Science, Hokkaido University

• HAGA Hisashi

  Division of Physics, Graduate School of Science, Hokkaido University

• NAGAYAMA Masafumi

  Division of Physics, Graduate School of Science, Hokkaido University

• Haga H

  Div. Of Biological Sciences Graduate School Of Sci. Hokkaido Univ.

• Haga Hisashi

  北海道大学 生物化学科

• Haga Hisashi

  Department Of Physics Faculty Of Science Hokkaido University

• Nagayama Masafumi

  Division Of Applied Physics Graduate School Of Engineering Hokkaido University

• KAWABATA KAZUSHIGE

  Transdisciplinary, Life Science Course, Faculty of Advanced Life Science, Hokkaido University

• TANAKA Yoshio

  Mechanical Systems Engineering, Graduate School of Engineering, Osaka Prefecture University

• HIRAI Yoshihiko

  Mechanical Systems Engineering, Graduate School of Engineering, Osaka Prefecture University

• KABUTO Masaaki

  Mechanical Systems Engineering, Graduate School of Engineering, Osaka Prefecture University

• Haga Hisashi

  Division Of Biological Sciences Graduate School Of Science Hokkaido University

• Kawabata K

  Transdisciplinary Life Science Course Faculty Of Advanced Life Science Hokkaido University

• Kawabata Kazushige

  Division Of Biological Sciences Graduate School Of Science Hokkaido University

• Hirai Yoshihiko

  Mechanical Systems Engineering Graduate School Of Engineering Osaka Prefecture University

• Kabuto Masaaki

  Mechanical Systems Engineering Graduate School Of Engineering Osaka Prefecture University

• Kawabata Kazushige

  Division Of Biological Sciences Graduate School Of Science

• Tanaka Yoshio

  Mechanical Systems Engineering Graduate School Of Engineering Osaka Prefecture University

• Haga Hisashi

  Division Of Biological Sciences Graduate School Of Science

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