Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts.
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概要
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Sequential images of the local stiffness distribution of living fibroblasts (NIH3T3) were captured under a culture condition using scanning probe microscopy in a force modulation mode. We found a clear relation between cell migration and local stiffness distribution on the cell: When cells were stationary at one position, the stiffness distribution of their cellular surface was quite stable. On the other hand, once the cells started to move, the stiffness in their nuclear regions drastically decreased. Possible explanations for the correlation between the cell migration and the cell stiffness are proposed. Cell Motil. Cytoskeleton 50:173-179, 2001. © 2001 Wiley-Liss, Inc.Wiley-Liss, Inc.
著者
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Kawabata K
Division Of Physics Graduate School Of Science Hokkaido University
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Haga H
Div. Of Biological Sciences Graduate School Of Sci. Hokkaido Univ.
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Haga Hisashi
北海道大学 生物化学科
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Haga Hisashi
Department Of Physics Faculty Of Science Hokkaido University
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KAWABATA KAZUSHIGE
Transdisciplinary, Life Science Course, Faculty of Advanced Life Science, Hokkaido University
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Haga Hisashi
Division Of Biological Sciences Graduate School Of Science Hokkaido University
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Kawabata K
Transdisciplinary Life Science Course Faculty Of Advanced Life Science Hokkaido University
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Kawabata Kazushige
Division Of Biological Sciences Graduate School Of Science
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