ニコチン酸dl-α-トコフェロール配合歯磨剤の歯周疾患予防効果に対する臨床的観察

概要

論文の詳細を見る
The effectiveness against periodontal disease of a dentifrice containing dl-a-tocopheryl nicotinate (V dentifrice) was tested comparing with placebo (P dentifrice) for 4 weeks. Subjects were 165 students of Josai Dental University who had no serious oral disease. This study was conducted with double blind method. The results were summarized as follows. 1) Subjects available for statistical analysis were 67 in each group. Subjects unavailable forstatistical analysis were 16 in V dentifrice group and 15 in P detifrice group. 2) V dentifrice was significantly superior to P dentifrice in improvement of PMA index (p<0.01) and redness (p<0.01). On the other hand, there was no significant difference in improvement of dental plaque and swelling between two groups. 3) After 4 weeks of the study, reduction rate of V dentifrice group and P dentifrice group were 40.6% and 27.1% in PMA index, 17.0% and 9.1% in redness, 13.7% and 5.9% in swelling, and 4.5% and 4.7% in dental plaque, respectively. 4) V dentifrice was significantly superior in general improvement to P dentifrice (p<0.01). The percentage of generally improved subjects of V dentifrice group and P dentifrice group were 77.6% and 56.7%, respectively. 5) No particular side effect was obserbed throughout the study.
特定非営利活動法人日本歯周病学会の論文
1982-12-28