多施設二重盲検法における歯周疾患に対する「XP-SN」の臨床評価

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It is wide recognized that the etiology of periodotal diseases is due to the local effects by the depositions at cervical region like dental plaque. In order to treat these diseases the removal of plaque and/or dental calculus by scaling and/or brushing, or the local application of anti-inflammatory agents are widely used. The anti-inflammatory agent -「XP-SN」- include Hinokitiol, Chlorhexidine, Glycyrrhetinic acid and dl-α-Tocopherol acetate as component. Redness, swelling, bleeding, pus discharge, depth of gingival pocket and movement of teeth were selected as indexes for clinical evaluation of periodontal diseases. The effect of tested agent was compared with placebo, and this study was conducted with double bind method. The results were summarized as follows : (1) Significant curings in redness, welling, bleeding, pus discharge and depth of gingival pocket were recognized through this study no matter what agents were used. The curing level was more significant in gingivitis than periodontitis. (2) In the case of whole patients, there were significant difference in recovery of redness and swelling between 「XP-SN」 and placebo (p < 0.01). (3) In the patients whose periodontal diseases were due to dental plaque and dental calculus, 「XP-SN」 was significantly more superior in the level and the time of recovery of redness (p < 0.01), swelling (p < 0.01) and pus discharge (p < 0.05) than placebo. (4) The general improvement of 「XP-SN」 on periodontal diseases was more than 62 percent. (5) No particular side effect was observed through this study.
特定非営利活動法人日本歯周病学会の論文
1977-12-28

多施設二重盲検法における歯周疾患に対する「XP-SN」の臨床評価

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