Evaluation of the State of Active Ingredients in Pharmaceutical Preparations Using Fourier Transform-Raman Difference Spectra
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概要
- 論文の詳細を見る
To examine the pharmaceutical application of Fourier transform (FT)-Raman spectroscopy, the state of active pharmaceutical ingredients (APIs) in a preparation of several forms was evaluated by investigating the Raman difference spectra between the preparation and excipient. The difference spectra indicated that APIs in alacepril tablets, caffeine sustained-release granules, and quinidine sulfate granules remained unchanged after the manufacturing process. However, the state of sparfloxacin in nanoparticles changed, although it remained unchanged in tablets or powders. These results show that the FT-Raman difference spectrum is expected to be utilized in the field of quality control of crystalline pharmaceutical preparations.
- 社団法人日本薬学会の論文
- 2006-12-01
著者
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岩崎 利信
Department Of Pharmaceutical Chemistry Graduate School Of Natural Science And Technology Okayama Uni
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斎藤 寛
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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御船 正樹
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical
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小崎 由香理
Department of Pharmaceutical Chemistry, Graduate School of Natural Science and Technology, Okayama U
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塚本 郁子
Faculty of Medicine, Kagawa University
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斎藤 まど香
Department of Pharmaceutical Chemistry, Graduate School of Natural Science and Technology, Okayama U
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北村 陽二
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical
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山口 俊和
Formulation Research Laboratory, Dainippon-Sumitomo Pharma Co. Ltd.
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御舩 正樹
岡山大学薬学部
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斎藤 寛
岡山大・薬
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山口 俊和
Formulation Research Laboratory Dainippon-sumitomo Pharma Co. Ltd.
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塚本 郁子
香川大学医学部
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北村 陽二
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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塚本 郁子
Faculty Of Medicine Kagawa University
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御船 正樹
Faculty Of Pharmaceutical Sciences Okayama University
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斎藤 まど香
Department Of Pharmaceutical Chemistry Graduate School Of Natural Science And Technology Okayama Uni
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小崎 由香理
Department Of Pharmaceutical Chemistry Graduate School Of Natural Science And Technology Okayama Uni
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御船 正樹
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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