T Cell Activation in Demyelinating Neuropathy Associated with "Benign" Anti-Myelin Associated Glycoprotein IgM Gammopathy and in MS : Soluble Interleukin-2 Receptor Levels in Serum and Cerebrospinal Fluid

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概要

• 論文の詳細を見る

• Demyelinating neuropathy (DN) associated with "Benign" anti-myelin associated glycoprotein (MAG) IgM gammopathy, and multiple sclerosis (MS) are disorders with presumed immunopathogenesis. To obtain evidence of T cell activation, we determined serum concentrations of soluble interleukin-2 receptors (sIL-2 R) in 25 patients with DN associated with "Benign" anti-MAG IgM gammopathy and cerebrospinal concentrations of sIL-2 R in 35 patients with MS. Both in DN associated with "Benign" anti-MAG IgM gammopathy and clinically active (relapsing phase, pretreatment stage) MS sIL-2 R were markedly increased compared with normal healthy controls. In MS sIL-2 R concentrations were not correlated with disease severity. These data shows that T cells are activated in DN associated with "Benign" anti-MAG IgM gammopathy and in MS.

• 北里大学の論文
• 2001-08-31

著者

• KANAZAWA Naomi

  Department of Inherited Metabolic Disease, National Institute of Neuroscience, NCNP

• ITO Hiroaki

  Department of Energy, Environmental Science, Graduate School of Engineering, Utsunomiya University

• SAITO Toyokazu

  Department of Neurology, Kitasato University Hospital

• Kanazawa Naomi

  Department Of Neurology Kitasato University East Hospital

• Kanazawa Naomi

  Department Of Inherited Metabolic Disease National Institute Of Neuroscience National Center Of Neur

• Saito Toyokazu

  Department Of Neurology Kitasato University East Hospital

• Ogino Yutaka

  Department of Neurology, Kitasato University East Hospital

• Ogino Mieko

  Department of Neurology, Kitasato University East Hospital

• Irie Sachiko

  Department of Neurology, Kitasato University East Hospital

• Kusunoki Junichi

  Department of Internal Medicine, Kitasato University School of Medicine

• Ogino M

  Department Of Neurology Kitasato University School Of Medicine

• Ogino Mieko

  Department Of Internal Medicine Kitasato University School Of Medicine.

• Irie Sachiko

  Department Of Neurology Kitasato University East Hospital

• Ogino Y

  Department Of Neurology Kitasato University School Of Medicine

• Ogino Yutaka

  Department Of Internal Medicine Kitasato University School Of Medicine.

• Ito Hiroaki

  Department Of Anesthesiology And Medical Crisis Management Nagoya City University Graduate School Of

• Ito Hiroaki

  Department Of Internal Medicine Kitasato University School Of Medicine

• Kusunoki Junichi

  Department Of Internal Medicine Kitasato University School Of Medicine

• Ogino Mieko

  Department Of Neurology Kitasato University School Of Medicine

• SAITO Toyokazu

  Department of Chemical Engineering for Resources, Mining College, Akita University

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