IgG Anti-GM1 Antibodies from Patients with Acute Motor Neuropathy are Restricted and Predominantly IgG1 and IgG3
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概要
- 論文の詳細を見る
Increased titers of IgG anti-GM1 antibodies are present in some patients with the Guillain-Barre syndrome, particularly with the motor axonal variant, and following infection with Campylobacter jejuni or parenteral administration of gangliosides. Information regarding the subclass distribution of the autoantibodies would help elucidate the mechanism of disease. The subclass distribution of IgG anti-GM1 or asialo-GM1 antibodies from 8 patients with acute motor neuropathy was determined by ELISA using mouse monoclonal antibodies to each IgG subclass. In all cases, including following Campylobacter enteritis or parenteral gangliosides, the IgG anti-GM1 or asialo-GM1 antibodies were predominantly IgG1 or IgG3. These subclasses are associates with immune responses to T-cell dependent antigens. T-cells are likely to participate in the disease.
- 北里大学の論文
- 1993-12-31
著者
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Ogino Mieko
Department Of Internal Medicine Kitasato University School Of Medicine.
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Latov Norman
Department of Neurology, College of Physicians and Surgeons, Columbia University.
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Latov Norman
Department Of Neurology College Of Physicians And Surgeons Columbia University.
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Latov Norman
Department Of Neurology Columbia Presbyterian Medical Center College Of Physicians And Surgeons Colu
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