Clinical and Immunological Studies of Polyneuropathy Associated with Monoclonal Gammopathy
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概要
- 論文の詳細を見る
We studied 36 patients with polyneuropathy and monoclonal gammopathies, of whom, 16 had an IgM, 11 had an IgG, and 7 had an IgA monoclonal gammopathy. The two remaining patients had a biclonal (IgM, IgG) gammopathy. Tweleve patients (65%) with monoclonal gammopathy of undetermined significance (MGUS) or nonmalignant IgM monoclonal gammopathy had high titers of myelin-associated glycoprotein (MAG) IgM antibodies by enzyme-linked immunosorbent assay and reacted with MAG by immunoblot. Morphological studies of affected sural nerves typically show the characteristics features of chronic demyelination in patients with IgM MGUS. The neuropathy in patients with anti-MAG IgM M-proteins is probably caused by M-protein autoantibody activity. Patients with IgG, IgA of MGUS had symmetrical sensorimotor polyneuropathy, and sural nerve biopsy in these patients showed axonal degeneration. M-protein autoantibody activity to peripheral nerve tissue was not observed by immunoblot in this group. M-proteins in patients with IgG, IgA of MGUS may have a different peripheral nerve tissue target.
- 北里大学の論文
- 1994-10-31
著者
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ITO Hiroaki
Department of Energy, Environmental Science, Graduate School of Engineering, Utsunomiya University
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SAITO Toyokazu
Department of Neurology, Kitasato University Hospital
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Kanazawa Naomi
Department Of Neurology Kitasato University East Hospital
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Saito Toyokazu
Department Of Neurology Kitasato University East Hospital
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Ogino Yutaka
Department of Neurology, Kitasato University East Hospital
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Ogino Mieko
Department of Neurology, Kitasato University East Hospital
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Irie Sachiko
Department of Neurology, Kitasato University East Hospital
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KOWA Hisayuki
The Department of Neurology, Kitasato University East Hospital
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KANAZAWA Naomi
Research Division of East Hospital, School of Medicine, Kitasato University
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Kyuno Katsuhiro
Department of Internal Medicine, Kitasato University School of Medicine
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Kowa Hisayuki
Department of Internal Medicine, Kitasato University School of Medicine
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Ogino M
Department Of Neurology Kitasato University School Of Medicine
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Ogino Mieko
Department Of Internal Medicine Kitasato University School Of Medicine.
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Irie Sachiko
Department Of Neurology Kitasato University East Hospital
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Ogino Y
Department Of Neurology Kitasato University School Of Medicine
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Ogino Yutaka
Department Of Internal Medicine Kitasato University School Of Medicine.
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Kowa Hisayuki
The Department Of Neurology Kitasato University East Hospital
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Kyuno Katsuhiro
Department Of Internal Medicine Kitasato University School Of Medicine
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Ito Hiroaki
Department Of Anesthesiology And Medical Crisis Management Nagoya City University Graduate School Of
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Ito Hiroaki
Department Of Internal Medicine Kitasato University School Of Medicine
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Ogino Mieko
Department Of Neurology Kitasato University School Of Medicine
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SAITO Toyokazu
Department of Chemical Engineering for Resources, Mining College, Akita University
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