フレンド白血病ウイルス感染マウスの免疫動態に及ぼす溶連菌製剤OK-432の影響

概要

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Effect of streptococcal preparation (OK-432) on host immune response was evaluated in four to five-week-old male ddY mice infected with Friend leukemia virus (FLV). Mice were devided into four groups by the differences of innoculation of FLV and treatment by OK-432. First group received only innoculation of FLV without treatment. Second group was treated with OK-432 after innoculation of FLV. Third group was treated with OK-432 preaviously and also after innoculation of FLV. Fourth group was normal control. The immune response to sheep red blood cell (SRBC) was examined from humoral immune aspect and it was evaluated by hemolysin plaque forming cell assay and hemagglutinin titration. Cellular immune response was studied by macrophage migration inhibition test (MIT) in which ovalubumin was used as antigen. Both the number of hemolysin plaque forming cell and hemaggulutinin titer were increased in the third group but very few in comparison with that of normal control group. These results showed that OK-432 protected slightly depression of antibody forming capacity to SRBC but could not enhance production of antibody. In the MIT, the greater part of first and second group showed over 95 percent in % migration index. However, the result of third group was similar to that of normal control. From these observations, it was suggested that OK-432 activated T cell but not B cell.
北里大学の論文
1978-04-30