インスリン自己免疫症候群例にみられたインスリン結合抗体のimmunoglobulin classならびにlight chain typeについて(1)

概要

論文の詳細を見る
In 12 patients with insulin autoimmune syndrome (IAS), classes of immunoglobulins and types of their light chains were studied by radioimmunoelectrophoresis and Christiansen's method. Eight out of 12 patients had been treated with thiamazole because of Graves' disease, and 2 out of the 8 patients showed hypoglycemia caused by autoimmunity to insulin. The other 4 showed hypoglycemic attacks without Graves' disease. As a control study serum samples were obtained from 13 diabetics treated with insulin. The results obtained are as follows: Classes of immunoglobulins; Antiinsulin-antibodies were found to be only in immunoglobulin G (IgG) both in patients with IAS and diabetics treated with insulin by radioimmunoelectrophoresis. By Christiansen's method, however, besides IgG, the antibodies were detected in IgM in 2 insulin-treated diabetics. Types of light chains of immunoglobulins; Insulin treated diabetics showed both K- and L-types of light chains by radioimmunoelectrophoresis. In patients with IAS, one out of 6 patients with hypoglycemic attack and 2 out of 6 patients without hypoglycemic attack showed both K- and L-types of light chains. In the remaining 9 with IAS, only K-type was present. In conclusion a characteristic structual difference of antibodies to insulin was observed in the light chains of the immunoglobulins between the patients with IAS and those treated with insulin.
北里大学の論文
1975-12-31