インスリン自己免疫症候群例の血中にみられるインスリン結合抗体のimmunoglobulin classならびにlight chain typeについて(2)

概要

論文の詳細を見る
In 12 patients with insulin autoimmune syndrome (IAS), types of light chains of anti-insulin antibodies were studied by specific precipitation method. Eight out of 12 patients had been treated with thiamazole because of underlying Graves' disease, 2 of whom developed hypoglycemia caused by autoimmunity to insulin. The other 4 patients without Graves' disease showed hypoglycemic attack. As a control study serum samples were obtained from 13 diabetics treated with insulin. The results obtained were as follows: Insulin-treated diabetics showed both K-and L-types of light chains except for 2 cases proving extremely low anti-insulin antibody titer. In 3 out of 6 patients with IAS with hypoglycemic attacks, whose serum samples were obtained in a short time after the onset of hypoglycemic attack, L-type and K-type were barely found, and in the remaining 3 patients only K-type was present. Accordingly, in patients with IAS with hypoglycemic attacks, the ratio of K to L-type (K/L) was much higher than that in the diabetics treated with insulin. In patients without hypoglycemic attack, 4 out of 6 showed both K- and L-types of light chains and the other 2 showed only K-type. On the basis of these results, it is considered that the antiinsulin antibody in cases of IAS consisted structually of a different type of light chain from the antibody in control subjects of diabetics under insulin treatment.
北里大学の論文
1976-02-29