アルコールの糖および脂質代謝に及ぼす影響

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Carbohydrate intolerance and hyperlipidemia have been known to be risk factors in atherosclerotic vascular disease. The present study was conducted to determine to what extent alcohol ingestion in man would cause the changes of plasma glucose and lipids in normal and atherosclerotic subjects. One hundred g of oral glucose tolerance tests, with and without 0.5g/kg alcohol ingestion 30 minutes prior to the test, were performed on each subject to measure glucose, immunoreactive insulin (IRI), free fatty acid (FFA), triglyceride, cholesterol, phospholipids and lipoprotein profile. Alcohol ingestion revealed a gradual increase of plasma TG with a concomitant increase of cholesterol in young and aged subjects. This would indicate that alcohol stimulates the release of pre-β lipoprotein from the liver. Under the present experimental conditions, alcohol failed to show glucose intolerance, but clearly increased plasma lipids. The result suggests that hyperlipidemia would be caused by alcohol ingestion and subsequently would result in atherosclerotic lesions.
北里大学の論文
1974-12-31

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