<原著>11β-水酸化ステロイド脱水素酵素タイプ2の調節因子に関する検討

概要

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We developed easy enzyme-linked immunosorbent assays to measure urinary free cortisone (E) and cortisol (F) and analyzed associations between 24-h urinary excretion of E, F or its ratio, uE/F, and clinical measures reflecting mineralocorticoid action. Two hundred nineteen healthy males without any medication were enrolled in this study. uE/F ratio was 1.10 ± 0.41 (mean ± SD), which has been considered as the most sensitive index of renal 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2) activity. A strong linear correlation between uE and uF was observed in a double reciprocal plot. Not uAld but uE/F ratio had negative correlations with 24-h urinary concentrations of Na and K. Similar correlation of uE with 24-h urinary concentrations of Na and K suggested that uE is a principal determinant of uE/F ratio. In contrast, uE/F ratio did not have a significant correlation with 24-h urinary excretion of Na or K, but uAld had a negative correlation with 24-h urinary Na excretion. These results suggest that renal HSD11B2 activity is an important factor regulating urinary electrolyte concentrations in contrast with aldosterone regulating urinary electrolyte excretions.
岐阜大学の論文
2002-11-30