<原著>CYP11B2遺伝子多型と食塩感受性心肥大

概要

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We studied the association of two common diallelic polymorphisms in the aldosterone synthase gene (CYP11B2), one in the promoter (-344T/C, in complete linkage disequilibrium with Lys 173Arg) and the other an intron 2 gene conversion, with blood pressure, urinary aldosterone or electrolytes excretion and echocardiographic measurements in a Japanese population. A significant linkage disequilibrium between these polymorphic loci was confirmed. Although the allele frequencies did not differ between normotensives and hypertensives or between higher- and lower-renin hypertensives, the subjects with -344C allele or intron 2 conversion (-) allele had mild association with the parameters of cardiac concentric hypertrophy, independently of blood pressures or hormonal levels. However, we have observed a positive correlation between left ventricular mass and 24hr urinary excretion of sodium and potassium in the subjects with -344CC genotype or intron 2 conversion (-)(-) genotype. These data suggest that the -344C allele, in a complete or significant linkage disequilibrium with the 173Arg allele or the conversion (-) allele, respectively, can be a risk factor for developing salt sensitive cardiac hypertrophy.
岐阜大学の論文
2002-11-30