マウス肺炎の病因学的研究

概要

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Etiological studies of pneumonia in mice were made on natural outbreaks, with special reference to P. pneumotropica, M. pulmonis, C. kutscheri and Sendai virus. Pulmonary consolidation and suppurative lesions with bronchiectasis were rarely detected in mice from either colonies free from all the organisms examined or those infected with P. pneumotropica and/or M. pulmonis. In colonies infected with Sendai virus, however, the lung lesions were demonstrated in 1.7 to 78.3% of mice, regardless of the presence or absence of other pathogens. Considerably high incidence of the pulmonary lesions, 7.6 to 20.0%, were observed in mice from all colonies infected with P. pneumotropica, M. pulmonis and Sendai virus. From the pulmonary lesions, M. Pulmonis was isolated at high frequencies and in a larger number, while some were detected from grossly normal lungs. With P. pneumotropica, the results were similar but the difference between the affected and normal lungs was less remarkable. Mice harboring both M. pulmonis and P. pneumotropica in their lungs were mostly positive for Sendai virus antibody. C. kutscheri was rarely isolated from pulmonary lesions in the present cases.
社団法人日本獣医学会の論文
1978-06-25