カドミウム長期経口投与による肝微細構造変化に対する亜鉛の影響

概要

論文の詳細を見る
The superimposed effects of oral zinc administration on cadmium-induced ultrastractural changes in rat livers were studied. Twenty female rats were divided into 4 groups. To the diet for group I was added 200 ppm Cd for daily about 10 g diet, to that for group II 200 ppm of Zn and that for group III 200 ppm of Cd and Zn each. The group IV was the control. All of the four groups were sacrificed after 9 months of administration. In addition to examine the liver by an electronmicroscope, Cd concentration in the liver was analyzed by atomic absorption sepctrophotometry. The Cd contents in the livers of group III were significantly reduced compared with those of group I. Apparent ultrastructural changes; i.e., deterioration of rough endoplasmic reticula, losses of glycogen particles, and proliferation of smooth endoplasmic reticula, were observed in the livers of group I. Meanwhile, these changes were significantly mild in those of group III. From these results, it is suggested that Cd inhibits protein synthesis and glycogen metabolism in the liver and that Zn partly protects the liver from Cd-induced ultrastructural changes.
社団法人日本産業衛生学会の論文
1981-03-20