Effects of n-Alkylamines on the Motility and Viability of Heterosigma akashiwo Cells

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The cytotoxic effects of positively charged liposomes and their components on Heterosigma akashiwo cells were investigated. Positively charged liposomes reduced cell motility and eventually caused cytolysis. Negatively charged and non-charged liposomes had little effect on cell motility and/or cell viability. Damage was also induced by a single application of some n-alkylamines. Among n-alkylamines tested, laurylamine (C_<12>) was most effective in reducing motility and causing cytolysis of cells. The extent of the deleterious effects increased with increasing concentrations of laurylamine and with the duration of treatment. The extent of damage to cells by laurylamine changed periodically during the cell cycle. The effects of laurylamine began to increase at the forth hour of the light period and began to decrease at the first hour of the dark period, under condition of 12 hours of light and 12 hours of darkness. Lauric and myristic acids, which each have a carboxyl group in place of the amino group of the corresponding alkylamines, laurylamine and myristylamine, had little effect on the cells.
日本植物生理学会の論文