Apparent Lack of Tetrodotoxin Biosynthesis in Captured Taricha torosa and Taricha granulosa
スポンサーリンク
概要
- 論文の詳細を見る
In order to explore the origin of the potent neurotoxin tetrodotoxin, feeding experiments were carried out using [2-^<14>C]-acetate, [guanido-^<14>C]-arginine, [ureido-^<14>C]-citrulline and [^<14>C (U)]-glucose on the newts Taricha torosa and Taricha granulosa. The precursors were administered by injection, by oral feeding, or by soaking the newts in a bath of water containing the radioactive precursors. None of these feeding experiments resulted in the incorporation of radioactivity into tetrodotoxin, though common metabolites such as cholesterol, amines, amino acids, and macromolecular compounds were significantly labeled. The toxicities of T. granulosa and T. torosa used for the experiment were found to be higher than those previously reported. They retained a high level of toxicity during their captivity, yet they were found to continuously release small amounts of toxins (2.5% of the total toxins in one year). When subjected to an electric shock, the newts released significant amounts of toxin.
- 公益社団法人日本薬学会の論文
- 1983-10-25
著者
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小林 優
Faculty Of Pharmaceutical Sciencces Hokkaido University
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清水 譲
Department Of Pharmacognosy And Environmental Health Sciences College Of Pharmacy University Of Rhod
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