Studies on the Constituents of Asclepiadaceae Plants. II. On the Struture of Cynanchogenin from Cynanchum caudatum Max.
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概要
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Hydrogenation of cynanchogenin (I), m.p. 167°, C_<28>H_<42>O_6,gave a dihydro compound (II). Alkaline hydrolysis of (I) gave an unsaturated acid (VIII) and deacylcynanchogenin (VII), C_<21>H_<32>O_5. The same treatment of (II) gave (VII) and a saturated acid (IX). The satruated acid was proved to be 3,4-dimethylpentanoic acid by synthesis . By the permanganate oxidation, the unsaturated acid was shown to be 3,4-dimethyl-2-pentenoic acid. Deacylcynanchogenin has one ketone group, one double bond, and four hydroxyl groups, two of which easily undergo acetylation. Reduction of cynanchogenin with lithium aluminum hydride gave a polyol compound (XIV), which was also obtained by the reduction of deacylcynanchogenin with sodium borohydride.
- 社団法人日本薬学会の論文
- 1960-04-25
著者
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三橋 博
Faculty of Pharmaceutical Sciences, Hokkaido University
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三橋 博
Research Institute For Biology & Chemistry Tsumura & Co.
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三橋 博
Faculty Of Pharmaceutical Sciences Hokkaido University
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清水 譲
Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University
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清水 譲
Department Of Pharmacognosy And Environmental Health Sciences College Of Pharmacy University Of Rhod
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