Marine Terpenes and Terpenoids.VII. : Minor Cembranoid Derivatives, Structurally Related to the Potent Anti-tumor-Promoter Sarcophytol A, from the Soft Coral Sarcophyton glaucum

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概要

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• Eight new cembranoids, sarcophytol M (3), sarcophytol N (9a), sarcophytol J (11a), sarcophytol H and its diacetate (15a and 15b), sarcophytol O (18), sarcophytol I (19a) and sarcophytol G (24a), and known cembranoids nephthenol (7) and sinulariol D (8), were isolated from the soft coral Sarcophyton glaucum.Their structures were determined from the spectroscopic properties and by chemical conversion.Sarcophytol M (3) was found to be the enantiomer of the known compound cembrenol from a terrestrial plant.Sarcophytol N (9a) and sarcophytol J (11a) were the geometrical isomers at C-3 of the major components sarcophytol A (1a) and sarcophytol B (2a), which are potent anti-tumor-promoters.Sarcophytol H and sarcophytol O were identical with the diols 15a and 18,respectively, which were previously synthesized from 1a.Sarcophytol I (19a) and sarcophytol G (24a) were the diastereoisomers of the known compounds sarcophytol E (22a) and sarcophytol D (21a), respectively, and their absolute configurations were determined by chemical conversion of two 11,12E-epoxides (20 and 23).

• 社団法人日本薬学会の論文
• 1989-03-25

著者

• 小林 優

  Faculty Of Pharmaceutical Sciencces Hokkaido University

• 小林 優

  北大薬

• 長部 克典

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 長部 克典

  Faculty Of Pharmaceutical Sciences Hokkaido University

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