CONFORMATIONAL STUDY OF THE CEMBRANOID SARCOPHYTOL A, A POTENT ANTI-TUMOR-PROMOTER

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概要

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• Conformational analysis of the marine cembranoid sarcophytol A (1a), potent anti-tumor promoter, was carried out using a newly introduced molecular mechanic and molecular dynamic program Discover. Four minimum-energy conformations were derived, in accordance with a previous results of the epoxidation of 1a, which afforded 7R, 8R/7S, 8S- and 11R, 12R/11S, 12S-epoxide pairs. The most stable conformation was the one having C-19 and C-20 directed opposite to C-18,with respect to the average plane of the fourteen-membered ring. X-Ray crystallography of sarcophytol A α-methoxy-α-trifluoromethylphenylacetate (1c) was carried out simultaneously. This confirmed the 14S absolute configuration of 1a but the conformation of crystalline 1c did not correspond to any of the four minimum-energy conformers of 1a.

• 公益社団法人日本薬学会の論文
• 1990-03-25

著者

• 小林 公子

  The Institute Of Physical And Chemical Research (riken)

• 小林 優

  Faculty Of Pharmaceutical Sciencces Hokkaido University

• 小林 優

  北大薬

• 宗像 弘明

  Ryoka Systems Inc.

• 野村 充代

  Ryoka Systems Inc.,

• 野村 充代

  Ryoka Systems Inc.

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