Fate of intraperitoneally Injected Liver Metallothionein in Rat Kidney

概要

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Isolated rat liver metallothionein was injected intraperitoneally into female rats to find whether or not the injected metallothionein was recovered from the kidneys with high copper content as in the case of rat kidney metallothionein induced by exposure to inorganic cadmium ion. The distribution patterns of cadmium and zinc among protein fractions in the kidney supernatants changed dramatically within one day after the injection. The changes were explained by the degradation and re-synthesis of the injected metallothionein in the kidneys. Copper was not found as a major metal in any metal-lothionein fractions obtained from the kidney supernatants. This is in marked contrast to cadmium ion-exposed rat kidney metallothionein. The relationships between the selective and profound toxicity of the injected metallothionein to the tubular lining cells and the changes of the chemical forms of cadmium were also discussed.
社団法人日本薬学会の論文
1979-03-25