Extents of Hepatic Zinc-thionein Induction in Mice given an Equimolar Dose of Various Heavy Metals
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概要
- 論文の詳細を見る
Male ICR mice were injected intraperitoneally with various heavy metals (chromium, manganese, iron, cobalt, nickel, zinc, selenium, indium and lead) at an equimolar dose (150μmol/kg body weight) to compare the abilities of the metals to induce zinc-thionein (Zn-Th) in the liver. Metallothionein (MT) level was determined for cadmium-replaced liver supernatant fractions by high performance liquid chromatography-atomic absorption spectrophotometry. All the metals induced Zn-Th to some degree ; the strongest inducers were zinc and indium, and the weakest was iron. Selenium, previously reported to be unable to induce MT, also gave a fairly high level of Zn-Th at the lower dose of 30 μmol/kg (it was lethally toxic at the standard dose). Changes in the concentrations of some essential metals in the liver were also determined by the use of an inductively coupled plasma-atomic emission spectrometer in order to correlate the extents of MT induction with the changes of essential metal levels.
- 社団法人日本薬学会の論文
- 1982-11-25
著者
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米谷 民雄
National Institute For Environmental Studies
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鈴木 和夫
School Of Pharmaceutical Science Kitasato University
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鈴木 和夫
National Institute for Environmental Studies
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米谷 民雄
Division of Basic Medical Sciences, National Institute for Environmental Studies
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鈴木 和夫
Division of Basic Medical Sciences, National Institute for Environmental Studies
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