Comparison of Properties of Two Isometallothioneins in Oxidation and Metal Substitution Reactions
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概要
- 論文の詳細を見る
The reactivity of two isometallothioneins (two isoforms of rat liver zinc- and cadmiumthioneins) was compared in vitro. Reactions characteristic of metal-thiol mercaptide bonds were selected as follows; oxidative formation of intramolecular disulfide bonds by 5,5'-dithiobis (2-nitrobenzoic acid), intra- and inter-molecular oxidations by air and ligand substitution reaction with ethylenediaminetetraacetic acid (EDTA). The relative ratio of the two isometallothioneins and the reaction products were determined by high performance liquid chromatograph-atomic absorption spectrophotometry. Metallothionein-I was shown to be more reactive than metallothionein-II in all reactions tested in this study.
- 社団法人日本薬学会の論文
- 1983-12-25
著者
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米谷 民雄
National Institute For Environmental Studies
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鈴木 和夫
School Of Pharmaceutical Science Kitasato University
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米谷 民雄
National Inst. Health Sci.
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鈴木 和夫
National Institute for Environmental Studies
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