Age- and Sex-Dependent Variations of Essential Metal Levels in Tissues and Responses to Dextran Sulfate Treatment Which Induces Zinc-Thionein
スポンサーリンク
概要
- 論文の詳細を見る
Age and sex dependencies of iron. calcium and zinc levels in liver, kidney and spleen were investigated in male and female mice (3-12 weeks old). To clarify the age and sex dependencies of responses to dextran sulfate treatment. 4- and 12-week-old mice were injected intraperitoneally with dextran sulfate and killed 24 h later. The most striking change was observed in splenic iron level. The level increased with age and a five (male)- or eight (female)-fold increase was observed within the experimental period. Dextran sulfate treatment produced a marked decrease of the splenic iron level and the response was larger in 12-week-old mice. The alterations of metal levels after dextran sulfate treatment in the supernatant and precipitated fractions were also studied.
- 社団法人日本薬学会の論文
- 1983-12-25
著者
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米谷 民雄
National Institute For Environmental Studies
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鈴木 和夫
School Of Pharmaceutical Science Kitasato University
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米谷 民雄
National Inst. Health Sci.
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鈴木 和夫
National Institute for Environmental Studies
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