β-ラクタム系抗生物質の薬学的研究(第4報)6-[D(-)-α-(4-Ethyl-2,3-dioxo-1-piperazinecarboxamido)phenylacetamido]penicillanic Acid(T-1220)の水溶液中および体液中の安定性

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Degradation pattern of 6-[D (-)-α-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido) phenylacetamido] penicillanic acid (T-1220) in aqueous solution was investigated. In acidic solution, T-1220B and T-1220D were found, while T-1220A, T-1220B, and T-1220C were identified in alkaline solution. Stability of T-1220 in aqueous solution and body fluid was measured by means of High Pressure Liquid Chromatography. T-1220 was more stable at neutral pH of 5.0-6.0,slightly unstable at acidic pH of 4.0,and markedly unstable at alkaline pH of 9.0. Stability of T-1220 in various body fluids seemed to depend on pH, and its degradation pattern was similar to that in aqueous solution.
社団法人日本薬学会の論文
1977-09-25