3(5)-〔2-(5-Nitro-2-furyl)vinyl〕-5(3)-(5-nitro-2-furyl)pyrazole誘導体の合成ならびに構造-抗菌活性ニトロフラン系化合物の薬学的研究(第19報)

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2-Halogeno-1,5-bis(5-nitro-2-furyl)-1,4-pentadien-3-one amidinohydrazone hydrochloride (II), on heating in dimethylformamide, was cyclized and deaminated to 3(5)-[2-(5-nitro-2-furyl)vinyl]-5(3)-(5-nitro-2-furyl)pyrazole (α-from) (III). Reaction of 2-halogeno-1,5-bis(5-nitro-2-furyl)-1,4-pentadien-3-one (I) with hydrazine yielded pyrazole derivatives (III and IV) which were most likely to be dimorphic. Alkylation of III or IV formed a mixture of N-alkyl isomers (VIIa-c) which were also prepared by the reaction of I and alkylhydrazine. Other N-substituted derivatives (VIId-f, VIII-XI) of III shown in Table I were prepared. Antibacterial activity of these compounds is shown in Table II.
公益社団法人日本薬学会の論文
1968-04-25