刺激性試験法に関する研究(第1報)酢酸筋注時の障害組織回復試験

概要

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The healing process of local lesions after the intramuscular injection of acetic acid into the muscularis vastus lateralis in rabbits was examined in order to establish a new method for determining local irritation due to intramuscular injection of drugs. It was assumed that the healing period of a lesion depends on its volume and found that the volume is closely correlated with the volume index (V.I.), i.e., the product of the major and minor axes of the largest cross section and the length of the lesion. Equations establishing the relationship between the V.I. and healing period of injection-produced lesions were worked out, on the basis of which it was possible to calculate the theoretical healing period of lesions with considerable accuracy by using the V.I. values two and or seven days after the injection. There was a marked loss of muscle weight 15 days or more after the injection of a highly concentrated solution, whereas the atrophy-time curves flattened with the healing of lesions. Histopathologically, marked fibrosis and fatty infiltrations were observed within and in the surrounding lesions in markedly atrophied muscles.
社団法人日本薬学会の論文
1975-11-25